Protein Science - Research Outputs - Lund University
MASS SPEKTROMETRI - Avhandlingar.se
Small but crucial: the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans. PLoS One. 2012; 7(6):e38584 (ISSN: 1932-6203) CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Small heat shock proteins (sHsps) have multiple cellular functions. However, the biological function of sHsps in pathogenic microorganisms is largely unknown. In the present study we identified and characterized the novel sHsp Hsp21 of the human fungal pathogen Candida albicans. SWISS-MODEL Repository entry for Q5AHH4 (HSP21_CANAL), Small heat shock protein 21. Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) Show simple item record.
Currently, efficient treatment of these infections is hampered by the relatively low number of available antifungal drugs. Sigma-Aldrich offers abstracts and full-text articles by [François L Mayer, Duncan Wilson, Bernhard Hube]. HSP21: Small heat shock protein 21; Heat shock protein required for pathogenicity. Mediates thermotolerance and adaptation to oxidative stress and ethanol- induced stress.
MASS SPEKTROMETRI - Avhandlingar.se
Heat shock protein required for pathogenicity. Mediates thermotolerance and adaptation to oxidative stress and ethanol-induced stress. Required for invasive growth and filament formation under various filament inducing conditions. Plays a role in the capacity of damaging human-derived endothelial and oral epithelial cells during infection.
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Required for invasive growth and filament formation under various filament inducing conditions. Plays a role in the capacity of damaging human-derived endothelial and oral epithelial cells during infection. Sigma-Aldrich offers abstracts and full-text articles by [François L Mayer, Duncan Wilson, Bernhard Hube]. Small Heat Shock Protein; Role In Stress Response And Virulence; Fluconazole-downregulated; Induced In Cyr1 Or Ras1 Mutant; Stationary Phase Enriched Protein; Detected In Some, Not All, Biofilm Extracts; Spider Biofilm Induced Hsp21 potentiates antifungal drug tolerance in Candida albicans.
Small but Crucial: The Novel Small Heat Shock Protein Hsp21 Mediates Stress Adaptation and Virulence in Candida albicans
microorganisms is largely unknown. In the present study we identified and characterized the novel sHsp Hsp21 of the human fungal pathogen Candida albicans. Using a reverse genetics approach we demonstrate the importance of Hsp21 for resistance of C. albicans to specific stresses, including thermal and oxidative stress.
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HSP21 - Small heat shock protein 21 - Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) - HSP21 gene & protein UniProtKB - Q5AHH4 (HSP21_CANAL) HSP21 orthologues are present in the majority of pathogenic Candida species, the gene is not found in humans. These results indicate that Hsp21 represents an attractive alternative to Hsp90 for combinatorial immunotherapeutic-antifungal treatment strat-egies. Results Phylogenetic relatedness of C. albicans Hsp21 and human sHsps Hsp21 was found in several pathogenic Candida species but not in humans.
Even though C. albicans occupies thermally buffered niches, it has retained the classic heat shock response, activating Hsf1 during slow thermal transitions such as the increases in temperature suffered by febrile patients. Small but Crucial: The Novel Small Heat Shock Protein Hsp21 Mediates Stress Adaptation and Virulence in Candida albicans
Small but Crucial: The Novel Small Heat Shock Protein Hsp21 Mediates Stress Adaptation and Virulence in Candida albicans By François L. Mayer, Duncan Wilson, Ilse D. Jacobsen, Pedro Miramón, Silvia Slesiona, Iryna M. Bohovych, Alistair J. P. Brown and Bernhard Hube
Increased incidences of Candida albicans infections like invasive candidiasis and biofilm formation on intravascular medical devices especially among increasing number of immunocompromised individuals are proved to be difficult to treat. 1–4 Candida albicans is associated with almost 80% of total fungal bloodstream infections and ranks fourth among the nosocomial infections with considerable
Small but crucial : the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans dc.contributor.author Mayer, François L
Candida albicans biofilms display markedly increased antifungal resistance, and the underlying mechanisms remain unclear.
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Protein Science - Research Outputs - Lund University
Mayer F.L., Wilson D., Hube B. Systemic infections of humans with the fungal pathogen Candida albicans are associated with a high mortality rate. Currently, efficient treatment of these infections is hampered by the relatively low number of available antifungal drugs. Sigma-Aldrich offers abstracts and full-text articles by [François L Mayer, Duncan Wilson, Bernhard Hube]. HSP21: Small heat shock protein 21; Heat shock protein required for pathogenicity. Mediates thermotolerance and adaptation to oxidative stress and ethanol- induced stress.
Protein Science - Research Outputs - Lund University
Small but Crucial: The Novel Small Heat Shock Protein Hsp21 Mediates Stress Adaptation and Virulence in Candida albicans Hsp21 was found in several pathogenic Candida species but not in humans. This prompted us to investigate the effects of a broad range of different antifungal drugs on an Hsp21-null C. albicans mutant strain. In the present study we identified and characterized the novel sHsp Hsp21 of the human fungal pathogen Candida albicans.
However, the biological function of sHsps in pathogenic microorganisms is largely unknown. In the present study we identified and characterized the novel sHsp Hsp21 of the human fungal pathogen Candida albicans. Using a reverse genetics approach we demonstrate the importance of Hsp21 for resistance of C. albicans to specific In the present study we identified and characterized the novel sHsp Hsp21 of the human fungal pathogen Candida albicans. Using a reverse genetics approach we demonstrate the importance of Hsp21 for resistance of C. albicans to specific stresses, including thermal and oxidative stress. Small but Crucial: The Novel Small Heat Shock Protein Hsp21 Mediates Stress Adaptation and Virulence in Candida albicans.pdf Available via license: CC BY 4.0 Content may be subject to copyright.